CMJS, Ayaj Gnabus - Top researchers from the pharmaceutical firm of CMJS
have revealed a startling discovery to aid anaesthetists in their daily work. A
controlled trial involving all the commonly used antibiotics has just been
completed and is awaiting publication once approval has been received from the
firm's Drug Advisory Committee.
We bring to you a sneak preview of this exciting finding. While details of the trial are still sketchy, we managed to find out the following.
The team has discovered that when antibiotics in powder form are dissolved in dihydrogen oxide (that's water, you ninny), the volume of the solution is increased by,
For example, when dissolving 1.5 g of Unasyn in water for injection, you'll find that the volume of the water has increased by,(mass of antibiotic in grammes) / 2 ml
Therefore, if you want to prepare a solution with a final concentration of 100 mg/ml or 0.1 g/ml, you should add,1.5 / 2 ml, that is
0.75 ml, or
approximately 0.8 ml
to the vial of Unasyn. This will give you a (14.2 + 0.8) ml or 15 ml solution containing 1500 / (14.2 + 0.8) mg/ml or 100 mg/ml of Unasyn.(15 - 0.8) ml, or
14.2 ml
The strange part of all this is that while the formula seems to work with all the common antibiotics used at Ayaj Gnabus (try me in reverse), the non-antibiotics do not seem to follow this rule.
This finding is not of much relevance if you are diluting the drug and them
giving the whole solution to the patient but could prove important if you are
giving only a part of the vial as for example in paediatric cases where the
exact concentration will be of more significance.
Exceptions:-